Abstract: Objective Objective To investigate the relationship between Toxoplasma gondii（TOX）infection and abnormal pregnancy outcomes. Methods Methods A total of 126 cases of abnormal pregnancy women in the Department of Obstetrics and Gynecology，the Fourth People’ s Hospital of Langfang from March to December 2013 were chosen as an experimental group，and 263 cases of normal pregnancy women of childbearing age as a control group. The TOX?IgM and ?IgG antibodies were detected by ELISA. The data in the two groups were processed and analyzed by SPSS13.0. Results Results The positive rates of TOX?IgM，?IgG in 126 cases of abnormal pregnancy women were 7.94% and 19.84% respectively，and 1.90% and 8.75% in the control group respectively，and there were significant differences between them（χ2 IgM = 6.82，χ2 IgG = 9.70，both P＜0.01） . The positive rates of TOX?IgM，?IgG in the normal pregnancy women were lower than those in 4 sub?groups of abnormal pregnancy women，and all the differences were statistically significant（ χ2 spontaneous abortion = 10.40，χ2 premature delivery = 9.03，χ2 embryo damage =4.32，χ2 birth defect = 4.04，all P＜ 0.05） . However，the TOX?IgM，?IgG positive rates in the 4 sub?groups of abnormal pregnancy women had no statistically signifi? cant difference（P > 0.05） . Conclusions Conclusions TOX infection could cause serious abnormal pregnancy outcomes. Therefore，the comprehensive control measures should be strengthened.

Key words: Toxoplasma gondii；Abnormal pregnancy；IgM antibody； IgG antibody

摘要： 目的 目的 探讨弓形虫感染与异常妊娠结局的关系。方法 方法 选择2013年3-12月廊坊市第四人民医院妇产科就诊 的126例异常妊娠结局妇女为实验组， 本地区263例正常妊娠育龄妇女为对照组， 采用酶联免疫吸附试验进行弓形虫 IgM、 IgG抗体检测， 对两组数据进行处理和分析。结果 结果 异常妊娠结局妇女弓形虫IgM、 IgG阳性率分别为7.94%和 19.84%， 对照组阳性率分别为1.90%和8.75%，两组差异均有统计学意义 （χ2 IgM =6.82、χ2 IgG =9.70， P均＜0.01）； 对照组弓 形虫IgM、 IgG阳性率明显低于各异常妊娠结局组， 差异均有统计学意义（χ2 自然流产 =10.40、χ2 早产 =9.03、χ2 胎停 =4.32、 χ2 出生缺陷 =4.04， P均＜0.05）。4种异常妊娠结局妇女弓形虫IgM、 IgG阳性率差异均无统计学意义 （P均＞0.05）。结论 结论 弓 形虫感染可致严重异常妊娠结局， 应采取综合措施预防孕妇弓形虫感染。

关键词: 弓形虫； 异常妊娠； IgM抗体； IgG抗体