Chin J Schisto Control ›› 2014, Vol. 26 ›› Issue (3): 326-.

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Research progress on Plasmodium vivax chloroquine resistance

LI Jiang-yan| LI Qian| FANG Qiang*   

  1. Department of Microbiology and Parasitology|Bengbu Medical College;Anhui Key Laboratory of Infection and Immunity|Anhui Province| Bengbu 233030| China
  • Online:2014-06-15 Published:2014-08-11
  • Contact: FANG Qiang

间日疟原虫氯喹抗性研究进展李

李江艳|李倩|方强*   

  1. 蚌埠医学院病原生物学教研室、 安徽省感染与免疫重 点实验室 (蚌埠 233030)
  • 通讯作者: 方强
  • 作者简介:李江艳| 女| 硕士。研究方向: 感染与免疫
  • 基金资助:
    美国NIH研究项目 (U19AI089672); 教育部科学技术研 究 重 点 项 目(211079);安 徽 省 自 然 科 学 基 金 (1308085MH160); 蚌埠医学院研究生科研创新计划项 目 (Byycxz302)

Abstract: Malaria remains a serious public health problem,especially in developing countries. With the deepening of the un? derstanding of vivax malaria,Plasmodium vivax is also attracting more and more attention. An effective drug treatment is the foun? dation of controlling or even eliminating malaria. In recent years,more and more reports of chloroquine? resistance Plasmodium vivax have been reported. Plasmodium vivax chloroquine resistance has been a focus problem in vivax malaria prevention and treat? ment. In this paper,the research progress on distribution situation,detection methods and molecular markers of Plasmodium vivax chloroquine resistance is summarized.

Key words: Plasmodium vivax;Chloroquine;Resistance; Molecular mark

摘要: 疟疾仍然是一个严重危害人类健康的公共卫生问题, 尤其多见于发展中国家。随着认识的深入, 间日疟也获得 越来越多的重视。有效的药物治疗是控制疟疾甚至消除疟疾的基石, 近年来已有越来越多的间日疟原虫氯喹抗性报道, 间日疟原虫氯喹抗性已成为间日疟防治中一个备受关注的问题。本文就间日疟原虫氯喹抗性的分布现状、 体内外检测方 法和分子检测标志物研究进展进行初步总结。

关键词: 间日疟原虫; 氯喹; 抗性; 分子标记物

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