Abstract: Objective To evaluate the long?term therapeutic effect of Ruangan pills on advanced schistosomiasis combined with ascites. Methods The data of 54 advanced schistosomiasis patients with ascites were collected，and the patients were divid? ed into two groups namely a treatment group and a control group according to whether taking Ruangan pills. The effective rates，im? provement status of symptoms and levels of serum albumin（ALB）and hyaluronic acid（HA）of the two groups were compared. Re? sults The effective rates of the treatment group and control group were 92.59% and 44.44%，respectively，and the difference be? tween them was statistically significant（P < 0.05） . After the treatment for 9 and 12 months，the percentages of patients without as? cites and patients with symptom improvement in the treatment group were 77.78% and 92.59%，92.59% and 96.30%，respective? ly，while those in the control group were 29.63% and 37.00%，48.15% and 51.85%，respectively，and the differences between the two groups by different time were all statistical significant（all P < 0.05） . After the treatment for 9 months，the percentages of patients with the normal levels of ALB and HA were 88.89% and 59.26%，while those in the control group were 40.74% and 14.81%，respectively，and the differences between the two groups were statistically significant（both P < 0.05） . Conclusion The long?term treatment of Ruangan pills can not only improve clinical symptoms but also control the ascites recurrence，however， the therapeutic effect and the recurrence rate of ascites in longer?term still need further observation.

Key words: Advanced schistosomiasis； Ascites；Hepatic fibrosis；Ruangan pill

摘要： 目的 目的 观察扶正化瘀药软肝丸长程治疗对腹水型晚期血吸虫病 （晚血） 的疗效。方法 方法 收集54例腹水型晚血患 者资料， 按是否服用软肝丸分成治疗组及对照组， 比较两组有效率、 腹水消退、 症状改善情况及血清白蛋白 （ALB） 和透明质 酸 （HA） 水平改善的情况。结果 结果 治疗组有效率为92.59%， 对照组有效率为44.44%， 两组差异有统计学意义 （P＜0.05）。 治疗后9、 12个月， 治疗组腹水阴性者所占比例分别为77.78%和92.59%， 症状改善例数所占比例分别为92.59%和96.30%， 对照组腹水阴性者所占比例分别为29.63%和37.00%， 症状改善例数所占比例分别为48.15%和51.85%； 两组差异均有统计 学意义 （P均＜0.05）。治疗后9个月， 治疗组ALB和HA水平正常者分别占88.89%和59.26%， 对照组分别占40.74%和 14.81%， 两组差异均有统计学意义 （P均＜0.05）。 结论 结论 软肝丸长程治疗腹水型晚血可改善临床症状， 控制腹水复发， 但 其更远期的疗效及复发率还有待进一步观察。

关键词: 晚期血吸虫病； 腹水； 肝纤维化； 软肝丸