Abstract: Schistosome cercariae must penetrate skin as an initial step to successfully infect the final host. Proteolytic en? zymes secreted from the acetabular glands of cercariae contribute significantly to the invasion process. Nowadays，the researches of molecular mechanism of schistosome infection mainly focus on the cercarial secretions including serine protease and cysteine prote? ase. Previous researches already showed that Schistosoma mansoni penetrates the skin mainly depend on cercarial elastease secret? ed by cercariae while Schistosoma japonicum penetrates the skin chiefly by cathepsin B2. The illustration of molecular mechanism of schistosome cecariae infection will accelerate the identification of novel vaccines and drug targets.

Key words: Schistosome； Cercariae； Infection mechanism； Protease

摘要： 尾蚴穿透宿主皮肤是血吸虫成功感染终宿主的第一步。尾蚴钻腺分泌的蛋白酶在穿透宿主皮肤过程中发挥了 重要作用。目前对于血吸虫感染分子机制的研究主要集中在包括丝氨酸蛋白酶和半胱氨酸蛋白酶在内的尾蚴分泌蛋白 酶上。已有研究表明， 曼氏血吸虫主要靠尾蚴分泌的弹性蛋白酶穿透宿主皮肤， 日本血吸虫则主要利用组织蛋白酶B2侵 入宿主体内。尾蚴入侵分子机制的阐明有助于新型血吸虫病疫苗的研制和药物靶点的发现。

关键词: 血吸虫； 尾蚴； 感染机制； 蛋白酶