Chin J Schisto Control ›› 2013, Vol. 25 ›› Issue (5): 555-.

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Clinical experience on treating Toxoplasma gondii infection during pregnancy by using acetyl spiramycin combined with azithromycin

TANG Hong-xia1 | XIONG Xue-feng1 |QIN Zhi-qiang2   

  1. 1 Heshan District Maternal and Child Health Hospital of Yiyang City in Hunan Province|Yiyang 413002|China;2. National Insti? tute of Parasitic Diseases|Chinese Centre for Disease Control and Prevention|WHO Collaborating Centre for Malaria|Schistosomia? sis and Filariasis|China
  • Online:2013-10-28 Published:2013-10-29

乙酰螺旋霉素联合阿奇霉素治疗孕期弓形虫感染的临床效果

唐宏霞1|熊学峰1|秦志强2   

  1. 1湖南省益阳市赫山区妇幼保健院 (益阳 413002); 2 中 国疾病预防控制中心寄生虫病预防控制所

Abstract: Objective To explore an effective therapy for pregnant Toxoplasma gondii infection by using acetyl spiramycin combined with azithromycin. Methods ELISA and PCR were used to diagnose and evaluate the therapy efficiency to toxoplasmo? sis in pregnant women. Results The serological test showed that the positive rates of specific antibodies IgM and IgG to Toxoplas? ma gondii in 285 pregnant women were 1.05%(3/285)and 5.97%(17/285),respectively. All the 3 cases of serum IgM positive pregnant women received the amniotic fluid PCR tests for Toxoplasma gondii DNA and 2 were positive,and they received spiramy? cin combined with azithromycin. After the therapy,their serum IgM antibody specific to Toxoplasma gondii and positive amniotic fluid PCR test for Toxoplasma gondii DNA turned to be negative. Conclusion Acetyl spiramycin in combination with azithromy? cin is effective in the treatment of pregnant toxoplasmosis.

Key words: Toxoplasma gondii;Acetyl spiramycin; Azithromycin; Pregnant; Therapeutic efficacy

摘要: 目的 目的 探讨螺旋霉素联合阿奇霉素治疗孕期弓形虫感染的综合治疗方法。方法 方法 应用ELISA方法检测孕妇血清 特异性弓形虫IgG和IgM抗体, 并采用PCR方法检测羊水中弓形虫感染情况; 选取其中3例弓形虫IgM抗体阳性孕妇作为 治疗对象, 应用螺旋霉素联合阿奇霉素进行综合治疗, 通过血清学特异性抗体检测和PCR检测结果初步判断其疗效。结 结 果 果 经ELISA检测, 孕期妇女血清特异性弓形虫IgG和IgM抗体的阳性率分别为5.97% (17/285) 和1.05% (3/285), 对3例血 清IgM抗体阳性孕妇的羊水进行PCR检测特异性弓形虫基因, 有2例呈阳性。经过2种药物的联合治疗, 这2例孕妇血清 特异性弓形虫IgM抗体滴度阴转, PCR检测产妇脐带血中弓形虫基因为阴性。结论 结论 螺旋霉素联合阿奇霉素治疗孕期弓 形虫感染安全、 有效。

关键词: 弓形虫; 螺旋霉素; 阿奇霉素; 孕期; 治疗效果

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