Abstract: Objective To explore the preparation of 5% niclosamide ethanolamine granules and evaluate its molluscicidal ef? fect. Methods The optimal formula was obtained by the selection of wetting agents，dispersants，adhesives and carriers. The mol? luscicidal effect of 5% niclosamide ethanolamine granules was measured by the spray methods in the laboratory and field. Re? sults The mixed 5% niclosamide ethanolamine，0.2% sodium lauryl sulfate，and 1% alkylphenol sulfonic polyxyethylene ether sulfonate were crushed by gas flow，and then mixed with 93.7% quartz sand and 0.1% polyvinyl alcohol water solution，drying to 5% niclosamide ethanolamine granules. The density，bulk density，and moisture of 5% niclosamide ethanolamine granules were 1.4 g/ml，1.3 g/ml，and 2.4%，respectively，and the hot storage stability was qualified. Under the lab condition，the death rates of Oncomelania hupensis snails sprayed with 0.5 g/m2 （7 d）or 1.0 g/m2 （1 d）of 5% niclosamide ethanolamine granules were higher than 95%. In the field，the death rates of the snails sprayed with 0.5 g/m2 （7 d）or 1.0 g/m2 （1 d）were higher than 85%. Conclu? sion There is a high molluscicidal effect of 5% niclosamide ethanolamine granules and it is suitable for field application.

Key words: Niclosamide ethanolamine；Oncomelania hupensis；Granule； Molluscicidal effect

摘要： 目的 目的 探讨5%杀螺胺乙醇胺盐颗粒剂的制备方法及其杀螺效果。 方法 方法 通过对润湿剂、 分散剂、 黏合剂和载体 进行筛选， 得出5%杀螺胺乙醇胺盐颗粒剂的最佳配方。将制得的氯硝柳胺乙醇胺盐颗粒剂进行堆密度、 松密度、 水分和热 储稳定性评价， 调查5%杀螺胺乙醇胺盐颗粒剂喷撒法的实验室和现场杀螺效果。结果 结果 5%杀螺胺乙醇胺盐颗粒剂的最 佳配方和制备方法为： 5%的杀螺胺乙醇胺盐、 0.2%的十二烷基硫酸钠、 1%的烷基酚聚氧乙烯基醚磺酸盐混合后， 经气流粉 碎机粉碎， 得到粉末； 再与93.7%的石英砂和0.1%的聚乙烯醇水溶液混合均匀， 烘干， 得杀螺胺乙醇胺盐颗粒剂。所制得的 颗粒剂为干燥、 自由流动的黄色颗粒， 无可见外来物和硬块， 粉尘少， 适于机器施药； 堆密度、 松密度和水分分别为1.4、 1.3 g/ml和2.4%， 热储稳定性合格。实验室采用0.5 g/m2 5%杀螺胺乙醇胺盐颗粒剂喷撒7 d后， 或> 1.0 g/m2 剂量喷撒1 d后， 钉 螺死亡率均> 95%； 现场采用0.5 g/m2 5%杀螺胺乙醇胺盐颗粒剂喷撒7 d后， 或> 1.0 g/m2 剂量喷撒1 d后， 钉螺死亡率均> 85%。 结论 结论 5%杀螺胺乙醇胺盐颗粒剂杀螺效果较好， 是一种适合现场应用的新型杀螺剂型。

关键词: 杀螺胺乙醇胺盐； 钉螺； 颗粒剂； 杀螺效果