Abstract: Objective To explore the effective therapy for liver fibrosis and refractory ascites. Methods A total of 54 cases of liver fibrosis and intractable ascites were randomly divided into an experimental group and a control group. The experimental group received the improved central venous catheter indwelling of intraperitoneal drainage，irrigation，cavity injection，combined with systemic comprehensive treatment. The control group received the routine paracentesis. Results The total effective rate was 82.1% in the experimental group，and the total effective rate was 57.7% in the control group （χ2 = 3.87， P＜0.05） . The hospitaliza? tion days，abdominal puncture times，ascites significantly effective time were（was）less or shorter in the experiment group com? pared with those in the control group（P < 0.05） . Conclusion The improved central venous catheter in peritoneal catheter is safe， effective， and convenient in the treatment of hepatic fibrosis and intractable ascites

Key words: Liver fibrosis ascites； Refractory ascites；Central venous catheter； Treatment efficacy

摘要： 目的 目的 探讨肝纤维化并顽固性腹水的综合治疗方法。 方法 方法 收集54例肝纤维化并顽固性腹水住院患者， 随机 分为实验组和对照组。实验组采用改良中心静脉导管腹腔内留置进行放液、 灌洗、 腔内药物注射， 并结合全身情况综合治 疗。对照组常规腹腔穿刺抽液。结果 结果 实验组总有效率82.1%， 对照组总有效率57.7%， 差异有统计学意义 （χ2 = 3.87， P＜0.05）。实验组住院天数、 腹穿次数、 腹水消退时间均少于对照组， 差异均有统计学意义 （P均＜0.05）。结论 结论 改良中心 静脉导管腹腔留置治疗肝纤维化并顽固性腹水安全、 有效、 方便。

关键词: 肝纤维化； 顽固性腹水； 中心静脉导管； 治疗效果