Abstract:

Objective To explore the clinical characteristics，early diagnosis，and treatment of patients with imported falci? parum malaria from Africa. Methods The clinical data of 91 imported falciparum malaria cases were analyzed by retrospective study. Results All the 91 cases had the history of mosquito bites. The clinical manifestation of these cases varied，including fe? ver，headache，chill，diarrhea，anemia，thrombocytopenia，proteinuria，damage of liver function，abdominal ultrasonographic presentations（enlarged liver and spleen） . All the patients were successfully treated with the combination therapy of artemether and primaquine. Conclusion The key procedures for treating imported falciparum malaria are earlier diagnosis and effective ther? apy. The combination therapy with artemether and primaquine shows a high efficacy and low side effect and low relapsed rate.

Key words: Falciparum malaria；Imported malaria； Clinical characteristics；Artemether；Primaquine

摘要：

目的 探索非洲输入性恶性疟的临床特征和早期诊断、 治疗的方法。方法 回顾性分析91例非洲输入性恶性疟的临床资料。结果 91例输入性恶性疟疾患者均有蚊虫叮咬史。临床表现复杂多样， 可出现发热、 头痛、 畏寒、 腹泻、 贫血、 血小板减少、 蛋白尿、 肝功能损害、 肝脾肿大等表现。应用蒿甲醚联合伯氨喹临床治愈率为100%。结论 早期诊断， 及时、 合理的处理是治疗输入性恶性疟疾的关键。蒿甲醚联合伯氨喹对输入性恶性疟疾有显著的临床疗效， 副作用少， 作用迅速， 复燃率低。

关键词: 恶性疟； 输入性疟疾； 临床特点； 蒿甲醚； 伯氨喹