Chin J Schisto Control ›› 2012, Vol. 24 ›› Issue (5): 594-597.

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Progress in research on techniques for prolonging half ?life of protein and polypeptide drugs

  

  • Received:2012-04-22 Revised:2012-04-22 Online:2012-10-11 Published:2012-10-11

蛋白质及多肽类药物长效化研究进展

  

  1. 江苏省血吸虫病防治研究所、卫生部寄生虫病预防与控制技术重点实验室(无锡214064)
  • 作者简介:江苏省血吸虫病防治研究所、卫生部寄生虫病预防与 控制技术重点实验室(无锡214064)
  • 基金资助:

    国家自然科学基金(30972581);江苏省自然科学基金(BK2008110)

Abstract:

Following the advancement in molecular biology and recombinant technology,the protein and polypeptide thera? peutics have become an important class of clinical drugs due to their unique superiority. However,the problems of stability and short half?life of proteins and peptides also vastly limit their further use in clinic. The focal points of this paper are to introduce the specific ways and the matters needing attention to increase the biological half?life of the therapeutic protein and polypeptide drugs.

Key words: Pharmacology;Protein;Polypeptide;Half?life;Immunogenicity

摘要:

随着分子生物学技术和基因重组技术的发展,蛋白质与多肽类药物凭借其独特的优势已逐渐成为一种重要的临床药物类型;但稳定性差,半衰期短的缺点也极大限制了其在临床上的广泛应用。本文针对目前延长蛋白质和多肽类药物半衰期的具体方法及其注意事项进行了综述。

关键词: 药理学;蛋白质;多肽;半衰期;免疫原性

CLC Number: