Abstract:

Microsatellites，namely simple sequence repeats（SSR），are simple tandemly repeated sequences with repeat units of 1-6 bp in length. As genetic markers，microsatellites are abundant and distributed throughout the eukaryotic genomes. Their advantages include high polymorphism and abundance，co ?dominance，selective neutrality and high reliability. In recent years，microsatellite markers are often used to study the biologically genetic diversity. In this paper，we briefly review the applica? tion of microsatellite technique in the study of Plasmodium spp. genetic diversity.

Key words: Microsatellite marker；Plasmodium spp.； Genetic diversity

摘要：

微卫星标记是以1~6个碱基为重复单位组成的简单串联重复序列， 其广泛存在于各类真核生物基因组中， 一般为散在分布的中等程度重复序列， 具有数量多、 多态性高、 共显性遗传、 选择中性和可重复性好等优点， 近年来常用于研究生物的遗传多态性。本文简述了微卫星标记技术基本原理、 优点和检测方法及其在疟原虫遗传多态性研究中的应用。

关键词: 微卫星标记； 疟原虫； 遗传多态性