Abstract:

  Objective  To evaluate the toxicity of suspension concentrate of niclosamide (SClxD for mollusciade in the field. Methods   According to the state standard of the People's Republic of China "The methods of toxicity test for agriculture register",  GB15670 - 1995, the experiments of acute toxicity on rats and fish were carried ouL Results more than 5 000 mg/kg respectively, and LCsocs) LDsocs) of SCN via mouth and skin with rats were of SCN via inbreathe with rats were more than 5 000 mg/ms. Based on the classification of appraising criterion on acute toxicity test, it belonged to a feebleness toxicity degree The eye and the skin stimulating tests with rabbits showed that it did not irritate the eyes and the skin  For fish, its acute toxicity was slightly lower than that of pure niclosamide, and markedly lower than that of pure niclosamide ethanolamine salt and WPN.  Condusions  SCN belongs to a feebleness toxicity degree and has a lower toxicity to fish  It should be a useful molluscicide in endemic areas of schistosomiasis.

Key words:  OncmneLania snail, Niclosamide, Suspension concentrate, Toxicity

摘要：

目的评价氯硝柳胺悬浮剂的毒性，为现场大规模应用灭螺提供依据。方法按照中华人民共和国国家标准GB 15670-1995《农药登记毒理学试验方法》和鱼类毒性试验方法进行。结果经口、经皮肤的LDso雌、雄性大鼠均>5 000 mg/kg，经呼吸道的LCso雌、雄性大鼠均>5 000mg/m3，该药经口、经皮肤、经呼吸道毒性均属微毒类药物；兔眼用药后，观察期内无不良反应，对眼无刺激性；皮肤用药后对皮肤无刺激性。与氯硝柳胺原药、氯硝柳胺乙醇胺盐原药和氯硝柳胺乙醇胺盐可湿性粉剂相比，氯硝柳胺悬浮剂对鱼急性毒性最低。结论氯硝柳胺悬浮剂属微毒类药物，对鱼的毒性低于其乙醇胺盐可湿性粉剂，适合于现场应用。

关键词:  钉螺；氯硝柳胺；悬浮剂；毒性