Abstract: This article reports one hepatic echinococcosis patient complicated with systemic sclerosis. His clinical manifesta? tions were the progressive fibrosis of the skin，sour regurgitation，and belching. The blood examination showed that eosinophils was reduced，and antinuclear antibody（ANA）was positive at 1 ∶100 in cytoplasm particle type. He was given prednisone ace? tate 25 mg，q. d.，aspirin 100 mg，q. d.，centella triterpenes cream 12 mg t. i. d.，esomeprazole 40 mg q. d.，and domperidone 10 mg t. i. d. After one week，the Rodnan skin score reduced from 27 to 17. The liver hydatid cyst resection was performed，and the follow?up showed that his clinical manifestations improved and the Rodnan skin score reduced further.

Key words: Echinococcosis；Systemic sclerosis；Fibrosis；Autoimmune disease

摘要： 本文报道1例肝包虫病合并系统性硬化的患者， 临床表现以皮肤进行性硬化、 反酸、 嗳气为主要症状， 血常规嗜 酸性粒细胞减少， 抗核抗体胞浆颗粒型1∶100。给予醋酸泼尼松25 mg Qd、 阿司匹林100 mg Qn、 积雪苷片12 mg Tid、 埃 索美拉唑40 mg Qd、 多潘立酮10 mg Tid治疗。患者皮肤硬化改善明显， Rodnan评分从入院治疗前的27分下降到17分。 手术切除肝棘球蚴包囊后， 患者系统性硬化相关症状进一步减轻， 随访患者Rodnan评分进一步下降。

关键词: 包虫病； 系统性硬化； 纤维化； 自身免疫疾病