Chin J Schisto Control ›› 2015, Vol. 27 ›› Issue (4): 26-.DOI: 10.16250/j.32.1374.2015105

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Progress of pattern recognition receptors of molluscs

GAO Qian|ZHAO Qin-ping| MA Xiao-xue| DONG Hui-fen*   

  1. Department of Parasitology|School of Basic Medical Sciences| Wuhan University|Wuhan 430071|China
  • Online:2015-08-21 Published:2015-08-24
  • Contact: DONG Hui?fen

软体动物模式识别受体研究进展

高倩|赵琴平|马晓雪|董惠芬*   

  1. 武汉大学基础医学院人体寄生虫学教研室 (武汉 430071)
  • 通讯作者: 董惠芬
  • 作者简介:高倩| 女| 硕士研究生。研究方向: 血吸虫与宿主的生物学及相互关系
  • 基金资助:
    国家自然科学基金 (81401685); 湖北省卫生和计划生育委员会血防专项 (WJ2015XB008)

Abstract: Molluscs have established complete innate immunity to defense against pathogens. The pattern recognition recep? tors(PRRs)are the sensory receptors of molluscs to resist outside invaders,as the first reactor to initiate the innate immune re? sponse. Some PRRs have been identified in several molluscs,including Toll?like receptors(TLRs),C?type lectins,galectins, lipopolysaccharide?β?1, 3?glucan binding protein(LGBP),C1q domain?containing protein(C1qDC),and peptidoglycan recog? nition protein(PGRP) . PRRs have various biological activities and play important roles in the defense system of molluscs. This paper reviews the research progress of PRRs in molluscs.

Key words: Mollusc; Pattern recognition receptor; Innate immunity; Toll?like receptors; Lectin; Galectin; Lipopolysaccha? ride?β?1, 3?glucan binding protein; C1q domain?containing protein; Peptidoglycan

摘要: 软体动物建立了复杂的固有免疫系统以对抗病原生物体的入侵。模式识别受体 (Pattern recognition receptors, PRRs) 是软体动物启动固有免疫应答的首要分子, 其种类甚多, 如Toll样受体、 C型凝集素及半乳凝素、 脂多糖葡聚糖结 合蛋白、 补体相关分子和肽聚糖识别蛋白等。PRRs具有多种生物学特性, 在软体动物的固有免疫中发挥着重要作用。 本文对软体动物PRRs的研究进展作一综述。

关键词: 软体动物; 模式识别受体; 固有免疫; Toll样受体; 凝集素; 半乳凝素; 脂多糖葡聚糖结合蛋白; 补体相关蛋白; 肽聚糖识别蛋白

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