Chin J Schisto Control

   

Researches on mechanism of cell toxicity caused by niclosamide

XU Ying|DAI Jian-rong*   

  1. Jiangsu Institute of Parasitic Diseases|Key Laboratory of Parasitic Disease Control and Prevention|Ministry of Health|Jiangsu Provincial Key Laboratory of Parasite Molecular Biology|Wuxi 214064|China
  • Received:2014-09-12 Online:2015-01-21 Published:2015-01-21
  • About author:徐颖|女|硕士研究生|研究方向:血吸虫病防治及杀螺药物研究

氯硝柳胺的细胞毒性机制研究

徐颖|戴建荣*   

  1. 江苏省血吸虫病防治研究所|卫生部寄生虫病预防和控制技术重点实验室|江苏省寄生虫分子生物学重点实验室(无锡 214064)
  • 基金资助:

    国家自然科学基金(81071379);江苏省领军人才(LJ201132)

Abstract:

Niclosamide is the most commonly used molluscicide. Along with a lot of application of niclosamide, more and more scientists studied its toxic effects to aquatic organisms as well as the related cell toxicity mechanism. This paper summarizes the toxicity on cell, organelle, enzyme, cell signaling pathway, and genetic material caused by niclosamide, and puts forward the future research direction.

Key words: Niclosamide, Cell, Toxicity, Mechanism

摘要:

氯硝柳胺是最常用的灭螺药物。随着该药物的大量应用,对其水生生物毒性作用及细胞毒性机制的研究越来越多。本文对氯硝柳胺引起的细胞、细胞器、细胞酶、细胞信号通路及遗传物质毒性进行了概述,并提出了今后的研究方向。

关键词: 氯硝柳胺, 细胞, 毒性, 机制

CLC Number: