中国血吸虫病防治杂志 ›› 2014, Vol. 26 ›› Issue (3): 300-.

• 短篇论著 • 上一篇    下一篇

华支睾吸虫病不同流行程度地区化疗措施的探索

方悦怡1|阮彩文1|高向雄2|谭覃3|陈娆娆4|郝阳5*   

  1. 1 广东省疾病预防控制中心 (广州 510300); 2 广东省 肇庆市疾病预防控制中心; 3 广东省顺德区疾病预防 控制中心; 4 广东省普宁市疾病预防控制中心; 5 人民 卫生出版社
  • 出版日期:2014-06-15 发布日期:2014-08-11
  • 通讯作者: 郝阳
  • 作者简介:方悦怡| 女| 硕士| 主任医师。研究方向: 华支睾吸虫病流行病学与防治

Research on chemotherapy measures in different Clonorchis sinensis infectiosity endemic areas

FANG Yue-yi 1 | RUAN Cai-wen1 |GAO Xiang-xiong2 |TAN Tan3 |CHEN Rao-rao4 |HAO Yang5*   

  1. 1 Center for Disease Control and Prevention of Guangdong Province|Guangzhou 511430| Guangdong Province| China;2 Center for Disease Control and Prevention of Zhaoqin City|Guangdong Province| China;3 Center for Disease Control and Prevention of Shunde District|China;4 Center for Disease Control and Prevention of Punin City|China;5 People’ s Medical Publishing House| China
  • Online:2014-06-15 Published:2014-08-11
  • Contact: HAO Yang

摘要: 目的 目的 探索人群华支睾吸虫病不同流行程度地区的防治化疗措施。方法 方法 选择广东省人群华支睾吸虫病高、 中、 低度流行区, 分别设立干预组和对照组, 干预组分别对3岁以上人群、 重点人群和感染者实施阿苯达唑驱虫干预措施; 对照组不采取任何措施。结果 结果 干预1年后, 干预组人群华支睾吸虫感染率显著降低, 高、 中度和低度流行区分别下降了 47.90%、 86.52%和100%; 肝脏B超异常率分别下降了26.50%、 31.00%和100%; 丙氨酸氨基转移酶异常率分别下降了 48.70%、 62.30%和100%,天冬氨酸氨基转移酶异常率分别下降了55.50%、 39.90%和100%。对照组人群所有指标无下降 趋势。结论 结论 人群华支睾吸虫病不同流行程度地区应采取不同的化疗措施。

关键词: 华支睾吸虫病; 阿苯达唑; 效果评价

Abstract: Objective To explore the suitable chemotherapy measures in different Clonorchis sinensis infectiosity endemic ar? eas. Methods The interventional groups and control groups were set up in the heavy,moderate and light C. sinensis infectiosity areas in Guangdong Province,respectively. In the intervention groups,the chemotherapy was administered among all the residents aged above 3 years in the heavy endemic areas,the chemotherapy was given among the focus populations in the moderate endemic areas,and the chemotherapy was administered among the residents infected with C. sinensis confirmed by stool examinations in the light endemic areas. No measures were carried out in the control groups. Results One year after the interventions,the C. sinensis infection rates of the interventional groups decreased by 47.90%,86.52% and 100%,the abnormal rates of liver B ultrasonic ex? aminations decreased by 26.50%,31.00% and 100%,the ALT abnormal rates decreased by 48.70%,62.30% and 100%,and the AST abnormal rates decreased by 55.50%,39.90% and 100% in the heavy,moderate and light endemic areas,respectively. There was no decreasing trend of above?mentioned indexes in the control groups. Conclusion In the different C. sinensis infectios? ity endemic areas, the different chemotherapy measures should be carried out.

Key words: Clonorchiasis sinensis;Albendazole;Effect evaluation

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