中国血吸虫病防治杂志 ›› 2012, Vol. 24 ›› Issue (1): 54-57.

• 论著 • 上一篇    下一篇

HIV合并隐孢子虫感染及影响因素分析

田利光1|汪天平2|程国金3|汪峰峰2|童小妹1|郭俭1|蔡玉春1|陈家旭1|周晓农1*   

  1. 1 中国疾病预防控制中心寄生虫病预防控制所| 世界卫生组织疟疾、 血吸虫病和丝虫病合作中心| 卫生部寄生虫病原与媒介生物学重点实验室 (上海200025); 2 安徽省血吸虫病防治研究所; 3 安徽省阜阳市疾病预防控制中心
  • 出版日期:2012-02-16 发布日期:2012-02-15
  • 通讯作者: 周晓农
  • 作者简介:田利光| 男| 博士。研究方向: HIV和寄生虫合并感染
  • 基金资助:

    国家传染病重大专项 (2008ZX10004?011)

Cross?section study on co?infection of HIV and Cryptosporidium

Tian Li-guang1| Wang Tian-ping2| Cheng Guo-jin3| Wang Feng-feng2| Tong Xiao-mei 1| Guo Jian1| Cai Yu-chun1| Chen Jia-xu1 , Zhou Xiao-nong1*   

  1. 1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China|2 Anhui Institute of Parasitic Disease, China|3 Fuyang Center for Disease Control and Prevention, Anhui Province, China
  • Online:2012-02-16 Published:2012-02-15
  • Contact: Zhou Xiao?nong

摘要:

目的 目的 了解HIV合并隐孢子虫感染情况及其影响因素。 方法 方法 对安徽省阜阳市309名HIV感染者粪便样本进行检测, 以确定其隐孢子虫感染情况, 并对研究对象进行问卷调查和血清学检测。采用单因素分析和多因素Logistic回归模型对合并感染的影响因素进行分析。结果 结果 共粪检302人, 隐孢子虫感染率为8.28%, 男性 (13.49%) 显著高于女性(2.92%), 差异有统计学意义 (P < 0.05)。多因素分析表明, 男性(OR = 6.700, 95% CI: 2.030, 22.114), 年龄< 42岁 (OR = 4.148, 95%CI: 1.348,12.761), 体内IL?2水平< 77 pg/ml (OR = 0.226, 95%CI: 0.076, 0.674), 个人卫生习惯与合并隐孢子虫感染有关(OR = 0.324, 95%CI: 0.105, 0.994)。结论 结论 HIV合并隐孢子虫感染率高, 男性、 年龄< 42岁、 体内IL?2水平较高以及个人卫生习惯较差的HIV感染者应作为隐孢子虫感染的重点防治对象。

关键词: HIV; 隐孢子虫;合并感染; 影响因素

Abstract:

Objective To investigate the co?infection status of HIV and Cryptosporidium, and explore the influencing factors associated with the co?infection. Methods A total of 309 people with HIV positive in Fuyang City of Anhui Province were recruit? ed and their fecal and blood samples were collected for examinations of Cryptosporidium spp. infection and the levels of hemoglo? bin, cytokines and CD4+ /CD8+ T?lymphocytes. Meanwhile, the questionnaire survey was conducted. Results Among 302 people involved in fecal examinations, the infection rate of Cryptosporidium spp. was 8.28%, and the difference between infection rates of the male (13.49%) and the female (2.92%) was statistically significant(P < 0.05) . The multivariate logistic regression model showed that 4 factors were significantly associated with the coinfection of HIV and Cryptosporidium spp, including male (OR = 6.700, 95% CI: 2.030, 22.114), younger than 42 years old (OR = 4.148, 95% CI: 1.348, 12.761), level of IL?2 below 77 pg/ml (OR = 0.226, 95%CI: 0.076, 0.674) and personal hygiene habits (OR = 0.324, 95% CI: 0.105, 0.994). Conclusion The co?infection rate of Cryptosporidium spp. and HIV is high, the key targets of control are the people who are male, younger than 42 years old, with high level of IL2 and poor personal hygiene habits.

Key words: HIV, Cryptosporidium, Co?infection, Influencing factor

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