中国血吸虫病防治杂志 ›› 2021, Vol. 33 ›› Issue (3): 293-.

• 临床研究 • 上一篇    下一篇

2例输入性非洲锥虫病的随访预后研究

李元元1△,陈小玲2△,刘青2,王新宇3,陈木新1,刘琴1*   

  1. 1 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心(上海 200025);2 福建医科大学附属协和医院;3 复旦大学附属华山医院
  • 出版日期:2021-07-09 发布日期:2021-07-09
  • 作者简介:李元元,女,硕士,研究实习员。研究方向:疾病控制 陈小玲,女,硕士,主治医师。研究方向: 脓毒血症、肝脓肿
  • 基金资助:
    国家科技重大专项(2018ZX10101002);国家寄生虫资源库(NPRC⁃2019⁃194⁃30);国家重点研发计划项目(2016YFC1202000)

Follow⁃up prognostic study on two imported patients with human African trypanosomiasis

LI Yuan⁃Yuan1△, CHEN Xiao⁃Ling2△, LIU Qing2, WANG Xin⁃Yu3, CHEN Mu⁃Xin1, LIU Qin1*   

  1. 1 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai 200025, China; 2 Fujian Medical University Union Hospital, China; 3 Huashan Hospital Affiliated to Fudan University, China
  • Online:2021-07-09 Published:2021-07-09

摘要: 目的 对2例罕见的输入性非洲锥虫病(human african trypanosomiasis,HAT)病例治疗后进行随访研究,评判治疗效果,从而为输入性锥虫病临床治疗提供参考依据。方法 1例输入性罗德西锥虫病病例在治疗完成后第1、3、11、25个月以及1例输入性冈比亚锥虫病病例在治疗完成后第1、3、8、12个月,分别检测患者脑脊液中白细胞计数及脑脊液和血液中锥鞭毛体,比较治疗时、治疗后生理生化指标变化,根据其检测结果进行治疗效果和预后评判。结果 罗德西亚锥虫病病例在治疗后第1、3、11、25个月,脑脊液中白细胞计数分别为1、1、4、2个/μL;冈比亚锥虫病病例在治疗后第1、3、8、12个月,脑脊液中白细胞计数分别为3、6、4、3个/μL。2例病例在随访中均未在脑脊液和血液中查见锥鞭毛体。结论 经过规范治疗,2例输入性锥虫病病例恢复良好,没有复发迹象。

关键词: 非洲锥虫病, 布氏锥虫罗德西亚种, 布氏锥虫冈比亚亚种, 预后

Abstract: Objective To investigate the prognosis of two rare imported patients with human African trypanosomias (HAT) after treatment in a follow⁃up study, and to evaluate the therapeutic efficacy, so as to provide insights into the treatment of imported HAT patients. Methods The white blood cells in cerebrospinal fluid samples and the trypomastigotes in cerebrospinal fluid and blood samples were monitored in an imported case with Trypanosoma brucei rhodesiense infection 1, 3, 11 and 25 months post⁃treatment and in an imported case with T. brucei gambiense infection 1, 3, 8 and 12 months post⁃treatment to evaluate the therapeutic efficacy and prognosis. Results There were 1, 1, 4 and 2 white blood cells in per μL of cerebrospinal fluid in the case with T. brucei rhodesiense infection 1, 3, 11 and 25 months post⁃treatment, and there were 3, 6, 4 and 3 white blood cells in per μL of cerebrospinal fluid in the case with T. brucei gambiense infection 1, 3, 8 and 12 months post⁃treatment. In addition, no trypomastigotes were identified in the cerebrospinal fluid or blood samples of either case with T. brucei rhodesiense or T. brucei gambiense infection. Conclusion Following standardized treatment, two imported cases with human African trypanosomiasis cases recover satisfactorily, without any signs of relapse.

Key words: Human African trypanosomiasis, Trypanosoma brucei rhodesiense, Trypanosoma brucei gambiense, Prognosis

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