关键词: 刚地弓形虫, 类风湿性关节炎, 恶性肿瘤, 精神分裂症, 无锡市

Abstract: Objective　To investigate the seroprevalence of Toxoplasma gondii infections among patients with rheumatoid arthritis, malignant tumors and schizophrenia in Wuxi City, so as to provide data support for the control of toxoplasmosis in these patients. Methods　A total of 205 cases with definitive diagnosis of rheumatoid arthritis, 257 cases with definitive diagnosis of malignant tumors and 235 cases with definitive diagnosis of schizophrenia were recruited, while 250 healthy volunteers served as controls. The demographic features were captured from the study subjects and serum samples were collected. The serum IgG and IgM antibodies against T. gondii were detected using an enzyme?linked immunosorbent assay (ELISA) in all study subjects, and the positive rates of anti?T. gondii IgG and IgM antibodies were compared between the patients and controls. Results　The seroprevalence of the anti?T. gondii IgG antibody was 20.98%, 24.12% and 24.68% in patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly greater than in healthy controls (χ2 = 31.54, 42.12 and 42.98, all P values < 0.01), and the seroprevalence of the anti?T. gondii IgM antibody was 1.46%, 2.72% and 1.70% among patients with rheumatoid arthritis, malignant tumors and schizophrenia, which were all significantly higher than in healthy controls (χ2 = 0.06, 1.52 and 0.21, all P values > 0.05). Conclusions　The patients with rheumatoid arthritis, malignant tumors and schizophrenia present with higher seroprevalence of the anti?T. gondii IgG antibody than healthy controls in Wuxi regions. Screening of T. gondii infections among the patients with rheumatoid arthritis, malignant tumors and schizophrenia should be intensified to prevent the damages caused by T. gondii infections.

Key words: Toxoplasma gondii, Rheumatoid arthritis, Malignant tumor, Schizophrenia, Wuxi City