中国血吸虫病防治杂志 ›› 2019, Vol. 31 ›› Issue (2): 139-142,147.

• 论著 • 上一篇    下一篇

云南省腾冲市住院病人溶组织内阿米巴感染情况及影响因素分析

王琦1,杨改革2,杨春利3,詹秀霞1,俞英昉4,张顺先4,田利光4*   

  1. China1 海南省妇幼保健院 (海口 570206);2 广东省广州市妇女儿童医疗中心;3 上海市皮肤病医院;4中国疾病预防控制中心寄生虫病预 防控制所、WHO热带病合作中心、科技部国家级热带病国际联合研究中心、国家卫生健康委员会寄生虫病原与媒介生物学重点实验 室
  • 出版日期:2019-05-24 发布日期:2019-05-26
  • 通讯作者: 田利光
  • 作者简介:王琦,男,本科,主治医师。研究方向:消化系统疾病
  • 基金资助:
    国家自然科学基金(81473022);中国博士后基金(2018M64303043)

Prevalence of Entamoeba histolytica infection and its risk factors in Tengchong City, Yunnan Provine: a hospital-based study

WANG Qi1, YANG Gai-Ge2, YANG Chun-Li3, ZHAN Xiu-Xia1, YU Ying-Fang4, ZHANG Shun-Xian4, TIAN Li-Guang4*   

  1. 1 Maternal and Children Health Hospital of Hainan Province, Haikou 570206, China; 2 Guangzhou Women and Children Medical Care Center, Guangdong Province, China; 3 Shanghai Dermatology Hospital, China; 4 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission,
  • Online:2019-05-24 Published:2019-05-26
  • Contact: TIAN Li?Guang

摘要: 目的 了解云南省腾冲市住院病人溶组织内阿米巴感染情况及其影响因素。方法 2016?07?01–2017?03?31,采用横断面调查方法对云南省腾冲市人民医院住院病例进行问卷调查。无菌采集其粪便样本,通过巢氏PCR检测溶组织内阿米巴感染情况。采用[χ2]检验和多因素logistic回归模型分析溶组织内阿米巴感染的影响因素。结果 共调查507名住院患者,其中10名患者感染溶组织内阿米巴,感染率为1.97%(95% CI:1.07%~3.59%)。溶组织内阿米巴感染者和非感染者身高(Z = -0.40,P = 0.69)、体重(Z = -0.34,P = 0.73)、体重指数(Z = -0.40,P = 0.69)和年龄(Z = -1.48,P = 0.14)差异无统计学意义。慢性腹泻(OR = 21.43,95% CI:5.04~91.23)和日常饮用水(OR = 11.28,95% CI:2.79~45.56)是人感染溶组织内阿米巴的影响因素。溶组织内阿米巴感染和腹胀(OR = 0.70,95% CI:0.09~5.56)、食欲不振(OR =0.50,95% CI:0.06~4.02)、皮肤瘙痒(OR = 0.79,95% CI:0.10~6.38)、肛周瘙痒(OR = 1.74,95% CI:0.21~14.07)及便秘(OR = 0.91,95% CI:0.13~7.33)无统计学关联。结论 云南省腾冲市住院病人溶组织内阿米巴感染率较高,慢性腹泻和饮用未煮沸的水与溶组织内阿米巴感染呈高度相关。

关键词: 溶组织内阿米巴, 危险因素, 住院病人, 腾冲市

Abstract: Objective To understand the infection status and risk factors of Entamoeba histolytica in inpatients in Tengchong City, Yunnan Province. Methods A cross?sectional study was conducted in the inpatients in Tengchong People’s Hospital, Yunnan Province. After obtaining the informed consent from the subjects, the stool samples were collected from 2016?07?01 to 2017?03?31, and nested polymerase chain reaction (PCR) was used to detect E. histolytica in the stool samples. Meanwhile, a structured questionnaire was used to record the demographic information and clinical symptoms for the patients. Results Totally 507 cases were recruited, and the detection rate of E. histolytica was 1.97% (10/507, 95% CI: 1.07%-3.59%) in all subjects. There were no significant differences between the inpatients with and without E. histolytica infection in the height (Z = -0.40, P = 0.69), weight (Z = -0.34, P = 0.73), body mass index (Z = -0.40, P = 0.69) and age (Z = -1.48, P = 0.14). Chronic diarrhea (OR = 21.43, 95% CI: 5.04-91.23) and daily drinking water (OR = 11.28, 95% CI: 2.79-45.56) were relevant to E. histolytica infection. No significant association was observed between E. histolytica infection and the clinical symptoms, such as abdominal distension (OR = 0.70, 95% CI: 0.09-5.56), inappetence (OR = 0.50, 95% CI: 0.06-4.02), itchy skin (OR = 0.79, 95% CI: 0.10-6.38), perianal pruritus (OR = 1.74, 95% CI: 0.21-14.07), and constipation (OR = 0.91, 95% CI: 0.13-7.33). Conclusion E. histolytica infection is high in inpatients in Tengchong City, Yunnan Province, and chronic diarrhea and drinking unboiled water were highly correlated with E. histolytica infection.

Key words: Entamoeba histolytica, Risk factor, Inpatient, Tengchong City

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