中国血吸虫病防治杂志 ›› 2019, Vol. 31 ›› Issue (1): 98-102.

• 特约综述 • 上一篇    

广州管圆线虫感染致病机制的研究进展

廖瑶1, 2,孙希1, 2*,吴忠道1, 2*   

  1. 1中山大学中山医学院寄生虫学教研室(广州 510080);2热带病防治研究教育部重点实验室
  • 出版日期:2019-04-09 发布日期:2019-04-09
  • 通讯作者: 孙希,吴忠道
  • 作者简介:廖瑶,女,硕士研究生。研究方向:广州管圆线虫致病机制
  • 基金资助:
    国家重点研发计划(2016YFC1200500);中山大学青年教师培育项目(17ykpy09)

Advances in pathogenic mechanisms of Angiostrongylus cantonensis infection

LIAO Yao1, 2, SUN Xi1, 2*, WU Zhong-Dao1, 2*   

  1. 1 Department of Parasitology, Zhongshan School of Medicine, Sun Yat?Sen University, Guangzhou 510080, China; 2 Key Laboratory of Tropical Diseases Control, Ministry of Education, China
  • Online:2019-04-09 Published:2019-04-09
  • Contact: SUN Xi, WU Zhong?Dao

摘要: 广州管圆线虫病是因感染了广州管圆线虫后其幼虫移行至宿主中枢神经系统,从而引起以嗜酸性粒细胞增多为特征、以脑炎和脑膜脑炎为主要临床表现的一种危害严重的食源性寄生虫病,阐明其致病机制对于广州管圆线虫病防治具有重要意义。本文主要就广州管圆线虫感染引起嗜酸性粒细胞增多性脑炎和脑膜脑炎机制研究进展作一综述。

关键词: 广州管圆线虫病, 嗜酸性粒细胞, 致病机制, 小胶质细胞, microRNA

Abstract: Angiostrongylosis, a food?borne parasitic disease, is caused by the migration of larvae of Angiostrongylus cantonensis to the host’s central nervous system after it is infected. It is a serious disease with eosinophilic encephalitis and meningoencephalitis as the main clinical manifestations. Understanding of its pathogenic mechanism is important for the prevention and treatment of angiostrongylosis. This paper reviews the mechanism of eosinophilic meningitis and meningoencephalitis caused by A. cantonensis infection.

Key words: Angiostrongylus cantonensis, Eosinophil, Pathogenic mechanism, Microglia, MicroRNA

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