中国血吸虫病防治杂志 ›› 2019, Vol. 31 ›› Issue (1): 77-85,93.

• 特约综述 • 上一篇    下一篇

蠕虫及肠道原虫感染与肠道菌群关系研究进展

徐梦,沈玉娟*   

  1. 中国疾病预防控制中心寄生虫病预防控制所、国家热带病研究中心、世界卫生组织热带病合作中心,科技部国家级热带病国际联合 研究中心、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室(上海 200025)
  • 出版日期:2019-04-09 发布日期:2019-04-09
  • 通讯作者: 沈玉娟
  • 作者简介:徐梦,女,硕士研究生。研究方向:寄生虫分子流行病学及寄生虫与肠道菌群相互作用关系
  • 基金资助:
    国家自然科学基金(81772224);国家科技重大专项(2018ZX10713001?004);国家公益性卫生行业科研专项(201502021)

Progress of research on the interplay between helminth and intestinal protozoa and gut microbiota

Xu Meng, Shen Yu-Juan*   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology, National Health Commission, Shanghai 200025, China
  • Online:2019-04-09 Published:2019-04-09
  • Contact: Shen Yu?Juan

摘要: 肠道菌群是人体最大最复杂的生态系统,与肠道病毒和寄生虫等共同栖息在人或动物肠道内。已有研究表明,肠道菌群紊乱与多种疾病的发生、发展及预后密切相关。定植在宿主体内的寄生虫可直接或间接影响肠道菌群及其与机体的相对稳态,而肠道菌群结构及多样性的改变也会影响寄生虫感染及疾病的发生、发展和预后。本文就蠕虫及肠道原虫与肠道菌群相互关系研究进展作一综述。

关键词: 蠕虫, 肠道原虫, 肠道菌群

Abstract: As the largest and most complex ecosystem in humans, gut microbiota resides in human or animal gastrointestinal tract with intestinal viruses and parasites. Previous studies have demonstrated that gut microbiota dysbiosis is strongly correlated with the development, progression and prognosis of multiple diseases. The parasites that are colonized in the host, may directly or indirectly affect gut microbiota and the gut microbiota?host homeostasis, and changes in the composition and diversity of gut microbiota may also affect parasitic infections and the development, progression and prognosis of parasitic diseases. This paper reviews the progress of research on the interplay between helminth and intestinal protozoa and gut microbiota.

Key words: Helminth, Intestinal protozoa, Gut microbiota

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