关键词: 曼氏血吸虫病；嗜酸性粒细胞；病原学检测；吡喹酮；输入性病例；北京市

Abstract: Objective To analyze the clinical features of 6 patients with imported schistosomiasis mansoni， including the epidemic history， clinical manifestations， laboratory tests and therapeutic effect， so as to provide references for improving the levels of diagnosis and treatment of physicians. Methods The clinical data of 6 patients with imported schistosomiasis mansoni from January 2009 to July 2016 were collected and analyzed. Results All the 6 imported patients with schistosomiasis mansoni had a clear history of cercarial infested water exposure. The main manifestations were continuous fever and eosinophilia. Three （50%） patients were accompanied with diarrhea. Anti?Schistosoma japonicum IgG antibody were cross positive in 2 （33.3%） patients， while live eggs of S. mansoni were explored in intestinal mucosa specimens of all the patients. CD3+CD8+ T cell ratio was decreased significantly but B cell ratio was elevated in all the patients， and the main immunoglobulin of the patients was IgG. Hydroperitoneum and splenomegaly signs were discovered by abdominal ultrasonography in 16.6% （1/6） of the patients. Multiple liver nodules and wall thickening of rectum and sigmoid colon were revealed by pelvic MR scan in 16.6% （1/6） of the patients. Colitis was found in all the patients， and 66.6% （4/6） of the patients were combined with multiple colonic ulcers by the electronic colonoscopy examination. Chronic inflammation and eosinophil infiltration were found in all the patients by rectum pathology. All 6 patients were cured with chemotherapy named praziquantel. Conclusion Comprehensive analysis of clinical data including epidemiological history， specific manifestations， laboratory tests and intestinal mucosa pathology may be benefit of the management of schistosomiasis mansoni.

Key words: Schistomiasis mansoni； Eosinophilia； Etiologic examination； Praziquantel Chemotherapy； Imported case； Beijing City