关键词: 晚期血吸虫病；乙型肝炎；肝硬化；凝血功能；血小板

Abstract: Objective To analyze the differences of coagulation parameters between patients with advanced schistosomiasis cirrhosis and hepatitis B cirrhosis under different degrees of liver function， so as to provide the evidence for further guidance of judging clinical condition and prognosis. Methods Sixty?three patients with advanced schistosomiasis cirrhosis and eighty patients with hepatitis B induced cirrhosis hospitalized in Jingzhou Central Hospital from January 2014 to June 2016 were served as an advanced schistosomiasis cirrhosis group and a hepatitis B cirrhosis group， respectively， and ninety?six gastropathy patients excluded from other diseases that might affect coagulation in the same period were served as a control group. The levels of PT， INR， Fib， TT， APTT， and PLT of the patients among the above 3 groups and the cirrhosis patients with different Child?Pugh classes were detected and compared. Results The differences of the levels of PT， INR， Fib， TT， APTT， and PLT among the 3 groups were statistically significant （F = 84.512， 81.672， 37.612， 104.475， 52.497， 102.233； all P ＜0.05）. The further analysis showed that PT， INR， TT， and APTT of both the advanced schistosomiasis cirrhosis and hepatitis B induced cirrhosis groups were longer than those of the control group， and the PLT levels of both the former 2 groups were lower than that of the control group （all P < 0.05）. Compared with the advanced schistosomiasis cirrhosis group， PT， INR， TT， and APTT of the hepatitis B induced cirrhosis group were longer， and the levels of Fib and PLT were lower （all P < 0.05）. Among those with the liver function of Grade A， the reduced degree of PLT in the patients with hepatitis B induced cirrhosis was more serious， while for those with the liver function of Grade B and C， the difference between the patients with advanced schistosomiasis cirrhosis and hepatitis B induced cirrhosis was not statistically significant （both P > 0.05）. Under all the grades of liver function， TT and APTT of the hepatitis B induced cirrhosis group was longer than those of the advanced schistosomiasis cirrhosis group， and the Fib level of the former was lower than that of the latter. Among those with the liver function of Grade A and B， PT and INR of the hepatitis B induced cirrhosis group were longer than those of the advanced schistosomiasis cirrhosis group； while for those with the liver function of Grade C， the difference between the two groups was not statistically significant（all P > 0.05）. Conclusions There exist differences of the damage degrees of coagulation function between the patients with advanced schistosomiasis cirrhosis and hepatitis B cirrhosis. When the damage degree of the liver function is lighter， the coagulation function in the patients with hepatitis B cirrhosis decreases more significantly； when the damage degree becomes more severe， APPT in the patients with hepatitis B cirrhosis extends more significantly， while the differences of PLT and PT between them are little.

Key words: Advanced schistosomiasis； Hepatitis B； Cirrhosis； Coagulation function； Platelet