中国血吸虫病防治杂志 ›› 2023, Vol. 35 ›› Issue (1): 104-.

• 综述 • 上一篇    下一篇

阿苯达唑治疗多房棘球蚴病研究进展

崔紫烟1,2,3,冶赓博1,2,3,于文昊2,3,王志鑫2,3,孔繁玉2,3,任利2,3*   

  1. 1青海大学附属医院肝胆胰外科(青海 西宁810012);2 青海大学医学院(青海 西宁810012);3 青海省包虫病研究重点实验室(青海 西宁810099)
  • 出版日期:2023-03-14 发布日期:2023-03-14
  • 作者简介:崔紫烟,女,硕士研究生。研究方向:棘球蚴病
  • 基金资助:
    青海省自然科学基金(2019⁃ZJ⁃7031)

Progress of researches on albendazole for treatment of alveolar echinococcosis C

UI Ziyan1, 2, 3, YE Gengbo1, 2, 3, YU Wenhao2, 3, WANG Zhixin2, 3, KONG Fanyu2, 3, REN Li2, 3*   

  1. 1 Department of Hepatobiliary and Pancreatic Surgery, Qinghai University Affiliated Hospital, Xining, Qinghai 810012, China; 2 Qinghai University Medical School, Xining, Qinghai 810012, China; 3 Qinghai Provincial Key Laboratory of Echinococcosis Research, Xining, Qinghai 810099, China
  • Online:2023-03-14 Published:2023-03-14

摘要: 多房棘球蚴病是由多房棘球绦虫感染引起的一种高致死率人兽共患寄生虫病。阿苯达唑为苯并咪唑类化合物之一,具有强大的杀灭寄生虫作用,且驱虫谱较广。对于不愿接受手术治疗、失去手术机会或身体状态差而无法耐受手术的多房棘球蚴病患者,使用阿苯达唑药物治疗可一定程度上延缓疾病进展。近年来,多房棘球蚴病相关实验研究取得大量成果。本文回顾了相关文献并对阿苯达唑治疗多房棘球蚴病研究进展进行综述,以期增加对阿苯达唑治疗多房棘球蚴病效果的认识,为未来用于临床治疗奠定基础。

关键词: 多房棘球蚴病, 阿苯达唑, 联合治疗

Abstract: Alveolar echinococcosis, caused by Echinococcus multilocularis infection, is a highly deadly zoonotic parasitic disease. As a benzimidazole compound, albendazole has a strong and broad⁃spectrum anti⁃parasitic action. For alveolar echinococcosis patients that are unwilling to receive surgical treatment, lose the timing for surgery, or are intolerant to surgery due to poor physical status, administration of albendazole may delay disease progression. Recently, a large number of advances have been achieved in experimental studies on alveolar echinococcosis. In order to increase the understanding of the therapeutic efficacy of albendazole for alveolar echinococcosis, this review summarizes the advances in albendazole treatment for alveolar echinococcosis, so as to provide insights into the clinical treatment of alveolar echinococcosis with albendazole.

Key words: Alveolar echinococcosis, Albendazole, Combination therapy

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