福建地区新生儿刚地弓形虫感染血清学调查

摘要/Abstract

摘要： 目的　调查福建地区新生儿刚地弓形虫感染血清学阳性率，为制定先天性弓形虫病防控措施提供参考依据。方法　以2017—2018年福建地区出生的1 045例新生儿作为研究对象，其中早产儿387例、足月儿658例。采集新生儿脐带血，检测并比较早产儿和足月儿血清抗弓形虫IgG抗体阳性率。收集早产儿和足月儿母亲肘静脉血，检测并比较早产儿和足月儿母亲血清抗弓形虫IgG抗体阳性率。结果　福建地区1 045例新生儿血清抗弓形虫IgG抗体阳性率为9.38%。387例早产儿血清抗弓形虫IgG抗体阳性率为18.35%，男婴和女婴血清抗体阳性率差异无统计学意义（17.69% vs. 18.75%，[χ2] = 0.07，P > 0.05）。658例足月儿血清抗弓形虫IgG抗体阳性率为4.10%，男婴和女婴血清抗弓形虫IgG抗体阳性率差异无统计学意义（4.14% vs. 4.08%，[χ2] = 0，P > 0.05）。早产儿血清抗弓形虫IgG抗体阳性率显著高于足月儿（[χ2] = 58.17，P < 0.01）。1 045例新生儿母亲血清抗弓形虫IgG抗体阳性率为15.02%，早产儿母亲血清抗弓形虫IgG抗体阳性率显著高于足月儿母亲（20.93% vs. 11.55%，[χ2] = 16.79，P < 0.01）。结论　福建地区早产儿及其母亲弓形虫感染血清学阳性率显著高于足月儿及其母亲；应加强孕前弓形虫感染检测和弓形虫病防护知识健康教育，从而有效降低先天性弓形虫病发病率。

关键词: 刚地弓形虫, 先天性弓形虫病, 新生儿, 血清学调查, 福建地区

Abstract: Objective　To investigate the seroprevalence of Toxoplasma gondii infections among neonates in Fujian Province, so as to provide insights into the development of interventions for the prevention and control of congenital toxoplasmosis. Methods　A total of 1 045 neonates delivered in Fujian Province from 2017 to 2018 were recruited, including 387 preterm infants and 658 full?term infants. Umbilical cord blood was sampled from all neonates, and the seroprevalence of anti?T. gondii IgG antibody was detected and compared between preterm and full?term infants. In addition, elbow venous blood samples were collected from neonates’ mothers, and the seroprevalence of anti?T. gondii IgG antibody was detected and compared between preterm and full?term infants’ mothers. Results　The overall seroprevalence of anti?T. gondii IgG antibody was 9.38% among the 1 045 neonates in Fujian Province. The seroprevalence of anti?T. gondii IgG antibody was 18.35% in the 387 preterm infants, and there was no significant difference in the seroprevalence of anti?T. gondii IgG antibody between male and female infants (17.69% vs. 18.75%, [χ2] = 0.07, P > 0.05). The seroprevalence of anti?T. gondii IgG antibody was 4.10% in the 658 full?term infants, and there was no significant difference in the seroprevalence of anti?T. gondii IgG antibody between male and female infants (4.14% vs. 4.08%, [χ2] = 0, P > 0.05). In addition, the overall seroprevalence of anti?T. gondii IgG antibody was 15.02% in all neonates’ mothers, and the seroprevalence was significantly greater in preterm infants’ mothers than in full?term infant’s mothers (20.93% vs. 11.55%, [χ2] = 16.79, P < 0.01). Conclusions　The seroprevalence of T. gondii infections is significantly higher in preterm infants and their mothers than in full?term infants and their mothers. Prenatal detection of T. gondii infections and health education pertaining to toxoplasmosis prevention and control knowledge are required to be strengthened to effectively reduce the incidence of congenital toxoplasmosis.

Key words: Toxoplasma gondii, Congenital toxoplasmosis, Neonate, Serological survey, Fujian Province

中图分类号:

R531.8

吴志辉，卓碧敏，邱华红，马梅，陈惠瑜，钟汇. 福建地区新生儿刚地弓形虫感染血清学调查[J]. 中国血吸虫病防治杂志, 2021, 33(1): 71-.

WU Zhi-Hui, ZHUO Bi-Min, QIU Hua-Hong, MA Mei, CHEN Hui-Yu, ZHONG Hui. Investigation on seroprevalence of Toxoplasma gondii infections among neonates in Fujian Province[J]. Chin J Schisto Control, 2021, 33(1): 71-.

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福建地区新生儿刚地弓形虫感染血清学调查

Investigation on seroprevalence of Toxoplasma gondii infections among neonates in Fujian Province

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