中国血吸虫病防治杂志 ›› 2019, Vol. 31 ›› Issue (3): 319-.

• 临床研究 • 上一篇    下一篇

瞬时弹性成像探测仪FibroScan在华支睾 吸虫病中的临床应用

钟彬1,吴健林1*,万孝玲2,吕国丽2,唐雯茜2,蒋智华2*   

  1. 1广西医科大学(南宁 530021);2广西壮族自治区疾病预防控制中心
  • 出版日期:2019-08-28 发布日期:2019-08-28
  • 作者简介:钟彬,女,硕士,医师。研究方向:传染病诊疗
  • 基金资助:
    广西医疗卫生适宜技术开发与推广应用项目(S2018090)

Clinical value of transient elastography (Fibroscan) in detection of clonorchiasis

ZHONG Bin1, WU Jian-Lin1*, WAN Xiao-Lin2, Lü Guo-Li2, TANG Wen-Qian2, JIANG Zhi-Hua2*   

  1. 1 Guangxi Medical University, Nanning 530023, China;2 Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, China
  • Online:2019-08-28 Published:2019-08-28

摘要: 目的 探索瞬时弹性成像探测仪FibroScan应用于华支睾吸虫病的临床意义,以期为患者驱虫治疗的疗效评估提供新思路。方法 采用FibroScan检测华支睾吸虫病确诊患者驱虫治疗前后的肝脏硬度(LSM)值,并收集患者年龄、性别、体质指数(BMI)、食用鱼生持续时间、食用鱼生总量等指标,评价其与LSM的相关性。结果 华支睾吸虫病确诊病例年龄、性别、BMI、食用鱼生持续时间、食用鱼生总量与治疗前LSM值间均无相关性(r/rs分别为0.189、0.073、0.180,0.071、–0.098、0.033,0.166、0.309、0.172,0.235、0.247、0.209,0.164、0.277、0.088;P均 > 0.05)。同一患者驱虫治疗前第7、8、9肋间的LSM值差异有统计学意义(F = 3.259,P < 0.05),而驱虫治疗后差异则无统计学意义(F = 0.851,P > 0.05),驱虫治疗后患者各肋间的LSM值均显著低于较驱虫治疗前(t = 6.724、5.603、2.884,P均 < 0.05)。结论 FibroScan可用于华支睾吸虫病患者驱虫治疗疗效评估,但在不同部位检测可影响LSM值。

关键词: 华支睾吸虫病, 瞬时弹性成像探测仪, 肝脏硬度, 疗效评估

Abstract: Objective To assess the clinical significance of transient elastography (Fibroscan) in detection of clonorchiasis, so as to provide new insights into the assessment of therapeutic efficacy of deworming. Methods The liver stiffness measurement (LSM) values were measured in parasitologically diagnosed clonorchiasis patients using Fibroscan before and after deworming, and the patients’ age, gender, body mass index (BMI), duration of raw fish consumption and total amount of raw fish consumption were collected for correlation analyses. Results The clonorchiasis patients’ age, gender, BMI, duration of raw fish consumption and total amount of raw fish consumption had no associations with pre?treatment LSM values (r/rs = 0.189, 0.073, 0.180; 0.071, –0.098, 0.033; 0.166, 0.309, 0.172; 0.235, 0.247, 0.209; 0.164, 0.277, 0.088; all P values > 0.05). There was a significant difference in the LSM values from the seventh, eighth and ninth intercostal space prior to deworming (F = 3.259, P < 0.05), and no significant difference was detected after deworming (F = 0.851, P > 0.05). The LSM values from the seventh, eighth and ninth intercostal space were significantly lower pre?deworming than post?deworming (t = 6.724, 5.603, 2.884; all P values < 0.05). Conclusions Fibroscan is feasible to assess the therapuetic efficacy of deworming in patients with clonorchiasis; however, measurement at various sites affects the LSM value.

Key words: Clonorchiasis, Transient elastography, Liver stiffness, Therapeutic efficacy assessment

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