中国血吸虫病防治杂志 ›› 2018, Vol. 30 ›› Issue (5): 513-517.

• 论著 • 上一篇    下一篇

中国华支睾吸虫病药物治疗现状分析

钱门宝|朱慧慧|陈颖丹|周晓农*   

  1. 中国疾病预防控制中心寄生虫病预防控制所、世界卫生组织热带病合作中心、科技部国家级热带病国际联合研究中心、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室(上海200025)
  • 出版日期:2018-12-01 发布日期:2018-12-01
  • 通讯作者: 周晓农
  • 作者简介:钱门宝|男|博士研究生|副研究员。研究方向:土源性和食源性蠕虫病防控技术和策略
  • 基金资助:
    瑞银集团慈善基金会项目(9051);上海市第四轮公共卫生体系建设三年行动计划(GWTD2015S06)

Analysis of current drug treatment against clonorchiasis in China

QIAN Men-bao| ZHU Hui-hui| CHEN Ying-dan| ZHOU Xiao-nong*   

  1. National Institute of Parasitic Diseases| Chinese Center for Disease Control and Prevention; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases| Ministry of Science and Technology; Key Laboratory of Parasites and Vector Biology| National Health Commission| Shanghai 200025| China
  • Online:2018-12-01 Published:2018-12-01
  • Contact: ZHOU Xiao?nong

摘要: 目的 分析目前我国华支睾吸虫病药物治疗现状,推动全国华支睾吸虫病药物治疗规范化和驱虫工作的开展。方法 从2016年上报的全国各地重点蠕虫病防治工作报表中,选取有华支睾吸虫病报告的10个省(自治区、直辖市)。从上述10个省(自治区、直辖市)中,抽取20个开展华支睾吸虫病治疗的县(区、市)。收集省级和县级华支睾吸虫感染者个体治疗方案和华支睾吸虫病群体性化疗方案,比较各地方案差异。结果 省级水平上,3个省有华支睾吸虫感染者个体治疗推荐方案,但10个省(自治区、直辖市)均无群体性化疗方案。县级水平上,华支睾吸虫感染者个体治疗中,13个采用吡喹酮,7个采用阿苯达唑。从12个县(区、市)获取明确的吡喹酮治疗方案,按感染者体重60 kg换算,治疗总剂量为3.6~18.0 g,服药时间1~6 d,服药次数3~18次;从4个县(区、市)获取明确的阿苯达唑治疗方案,按感染者体重60 kg换算,治疗总剂量为0.8~8.4 g,服药时间2~7 d,服药次数2~14次。县级水平上,只有1个县开展了群体性化疗(具体为选择性化疗)。结论 目前,我国缺乏华支睾吸虫病群体性化疗方案。虽然多地开展了华支睾吸虫感染者个体治疗,但治疗方案差异较大,在药物种类、剂量、服用次数和时长等方面存在显著差异。需要制定我国华支睾吸虫病群体性化疗策略指南,在国家层面推动华支睾吸虫个体感染者药物治疗方案的标准化。

关键词: 华支睾吸虫病;治疗;群体性化疗;个体治疗

Abstract: Objective To analyze the current drug treatment against clonorchiasis in China, in order to promote the standardization of drug treatment and national deworming for clonorchiasis. Methods All the 10 provinces were enrolled, which reported clonorchiasis in the work report for important helminthiasis in 2016. Then, 20 counties were selected from these 10 provinces. The data on drug treatment including both mass chemotherapy and individual treatment against clonorchiasis were collected and compared. Results All the 10 provinces had no guideline for mass chemotherapy, while only 3 had that for individual treatment against clonorchiasis. Out of 20 counties, only 1 implemented mass chemotherapy. Among these 20 counties, 13 applied praziquantel in individual treatment, while other 7 employed albendazole. In the 12 counties with clear protocol for praziquantel, the total dosage for a man of 60 kg ranged from 3.6 to 18.0 g, the days and times for administration ranged from 1 to 6 and from 3 to 18, respectively. In the 4 counties with clear protocol for albendazole, the total dosage for a man of 60 kg ranged from 0.8 to 8.4 g, the days and times for administration ranged from 2 to 7 and from 2 to 14, respectively. Conclusions Nowadays, the guideline on mass chemotherapy for clonorchiasis is inadequate in China. Although individual treatment is applied in many areas, the protocols vary in drugs, dosage, and days and times for treatment. Thus, the national guideline of mass chemotherapy for clonorchiasis should be established, while the protocols for individual treatment should be standardized.

Key words: Clonorchiasis; Treatment; Mass chemotherapy; Individual treatment

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